Symbol
Name
ID

Lig4
ligase IV, DNA, ATP-dependent
MGI:1335098

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes

Increased circulating IgA level

Increased circulating IgG level

Decreased circulating antibody level

Paraproteinemia

Acute lymphoblastic leukemia

Chronic sinusitis

Lymphadenopathy

Splenomegaly

Hepatosplenomegaly

Peritoneal abscess

Psoriasiform dermatitis

Asthma

Recurrent respiratory infections

Disease(s) Associated with LIG4

DNA ligase IV deficiency

multiple myeloma

pancreatic cancer

Mouse Phenotypes

increased T cell apoptosis

decreased T cell proliferation

intestinal inflammation

abnormal thymus morphology

decreased thymus weight

small thymus

decreased thymocyte number

abnormal lymphopoiesis

abnormal B cell differentiation

abnormal class switch recombination

arrested B cell differentiation

abnormal T cell differentiation

abnormal T cell receptor V(D)J recombination

abnormal T cell receptor beta chain V(D)J recombination

decreased double-negative T cell number

decreased double-positive T cell number

arrested T cell differentiation

abnormal lymphocyte cell number

decreased B cell number

increased NK cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

absent CD8-positive, alpha-beta T cells

increased CD8-positive, alpha-beta T cell number

decreased lymphocyte cell number

abnormal regulatory T cell morphology

decreased spleen weight

small spleen

decreased splenocyte number

abnormal B cell activation

decreased IgA level

decreased IgD level

decreased IgG2b level

decreased IgG3 level

decreased IgG level

decreased IgM level

decreased immunoglobulin level

abnormal T cell activation

abnormal immune system morphology

abnormal immune system cell morphology

abnormal immune system organ morphology

abnormal immune system physiology

impaired humoral immune response

decreased interferon-gamma secretion

decreased interleukin-13 secretion

increased anti-chromatin antibody level

increased anti-double stranded DNA antibody level

liver inflammation

Availability

Mouse Genotype

Lig4^m1Btlr/Lig4^m1Btlr

Lig4^m2Btlr/Lig4^m2Btlr

Lig4^tiny/Lig4^tiny

Lig4^tm1Fwa/Lig4^tm1Fwa

Lig4^tm2.1Fwa/Lig4^tm2.1Fwa

Lig4^tm3.1Fwa/Lig4^tm3.1Fwa
Tg(Cr2-cre)3Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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